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The results showed that knockdown of DRP1 had no significant effect on the expression of the above-mentioned genes in ATC cell lines 8505 C and Hth-7, except for a slight upregulation of GCLC and downregulation of GCLM in 8505C cells, and a mild upregulation of GCLM in Hth-7 cells (Fig

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As the combination of catalytic and regulatory subunits of GCS contributes to the de novo synthesis of GSH, this age related alteration in expression of this enzyme subunit may be a significant contributory factor in leading to the lower GSH levels

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Ding J., Ji J., Rabow Z., Shen T., Folz J., Brydges C.R., Fan S., Lu X., Mehta S., Showalter M.R., Zhang Y., Araiza R., Bower L.R., Lloyd K.C.K., Fiehn O

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