Synergy is inferred from the individual mechanisms, not demonstrated in combination: GHK-Cu: Cosmetically Focused Clinical Data Split-face human dermatology trials on wrinkle depth and skin density (n usually under 50 per arm) Microarray gene mapping (4,000+ genes)
FIGURE 6 Activation of Adaptive Stress Responses by AQ-QI and DEAQ-QI and Effects of GSTP1 The stress responses induced by AQ-QI and DEAQ-QI exposure were measured with a high-content image-based BAC-GFP stress responses reporter assay for oxidative stress, ER stress, DNA damage stress and inflammatory stress (Wink et al., 2014, 2017)
In vitro and animal studies suggest it may stimulate collagen I and III production and promote matrix metalloproteinase regulation, processes central to skin and tissue health
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