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Elevated cAMP levels subsequently activate protein kinase A (PKA) and Rap guanine nucleotide exchange factor 4 (RAPGEF4, also known as EPAC2)

Where positive effects have been observed, the magnitude of weight loss is typically smallgenerally in the range of 0.5-2 kgwhich may not be clinically meaningful for most individuals seeking weight management

doi: 10.1093/jmcb/mjad014

Nystrom, T

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Patient selection criteria To summarize, GLP-1 RAs are particularly effective for individuals with T2D requiring enhanced glycemic control and especially beneficial for overweight or obese patients, as they help promote weight loss