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Target Range: Many research-style protocols aim for ~200250 mcg daily during the main phase

However, when the bleeding is fast, there isnt enough time for this process to happen

Upon bile acid activation, hepatic FXR induces expression of small heterodimer partner (SHP), which suppresses CYP7A1 and CYP8B1 gene transcription, thereby reducing bile acid synthesis ( FXR also participates in regulating glucose and lipid metabolism

Frontiers in Neuroendocrinology , 1998 A foundational review introducing GHRP biology and differentiating the GHS pathway from GHRH

10.4161/psb.6.5.15126 Plant Signal