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When to Call Your Doctor Severe abdominal pain Significant bloating or abdominal swelling Persistent nausea or vomiting Inability to pass gas, which can sometimes be a sign of a blockage in the colon Blood in the stool Black or tarry stools, which may indicate bleeding higher in the digestive tract Pencil-thin stools, which can be a sign of a narrowing or blockage Unexplained weight loss beyond what would be expected from the medication Fever A sudden change in bowel habits A lack of bowel movement for three to seven days, despite making lifestyle changes or taking over-the-counter medications New or worsening constipation after previously doing well on a GLP-1 medication Symptoms that persist for more than a few weeks despite treatment Resources We Trust Cleveland Clinic: Could You Be Pooping Better

See semaglutide while trying to get pregnant , tirzepatide while breastfeeding , and GLP-1 while breastfeeding for detailed guidance

Be alert for symptoms of hypoglycaemia including trembling, sweating, confusion, dizziness, and palpitations

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The prevalence of glucose-lowering medication use was similar between SGLT2i users and non-users, except for metformin