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If youre concerned, message your prescribing clinician through the TrimRx platform

New England Journal of Medicine, 387 (3), 205216.

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This is especially risky if you are prescribed diuretics as part of your PH treatment as it could lead to kidney injury

However, Southend produces a compounded version that is not FDA-approved, includes vitamin B6 as an adjunct ingredient, and comes in multi-dose vials rather than pre-filled pens

In 2026, the Phase 3 SYNCHRONIZE-1 trial reported topline mean weight loss of about 16.6% at 76 weeks versus about 3.2% on placebo