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Sugiura et al., 2010

Oral semaglutide, lixisenatide and albiglutide did not increase the risk

Accordingly, these findings collectively suggest a decrease in neutrophil-driven intestinal inflammation and improved mucosal integrity indicated by decreased fecal calprotectin, a well-established biomarker of intestinal inflammation [108]

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Obviously well have to watch for this in the phase 3 Eloralintide trials as well, but given its highly selective activity on Amylin receptors and lack of engagement on the calcitonin receptor, it may not develop into an issue at the doses Lilly is testing

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