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9,10,11 Advancing to Triple Therapy Some studies have demonstrated efficacy of achieving glycemic control when a third oral agent is added to two-medication therapy

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The progression of ALS is driven by a complex interplay among astrocyte abnormalities, chronic neuroinflammation, and TDP-43 aggregation, forming a unique web of interconnected pathologies

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There is a substantial body of evidence suggesting that neuroinflammation and immune dysfunction play key roles in the etiologic cascade that leads to neurodegeneration and AD/ADRD, as discussed in Chapter 3