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COURAGE was designed to investigate the quality of weight loss in patients with obesity (BMI 30 kg/m2)

These results emphasize the potential of GLP-1 RAs in individualized treatment for this population

On the one hand, it feels so peaceful to no longer have those constant thoughts about food rattling around in my brain

All 3 trials showed non-inferiority for cardiovascular safety compared placebo, and in some cases showed impressive reductions in adverse cardiovascular outcomes

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A study that compared 24 obese patients with MC-4R deficiency to 80 healthy controls (40 obese and 40 lean) found that those with MC-4R mutations consumed significantly more high-fat meals