SGLT-2 inhibitors carry the sharper version of this, the risk of diabetic ketoacidosis, which is why they are used only under strict protocols
Lauren A Jones, Daniel I Brierley, GLP-1 and the Neurobiology of Eating Control: Recent Advances, Endocrinology , Volume 166, Issue 2, February 2025, bqae167, Gabe MBN, Breitschaft A, Knop FK, Hansen MR, Kirkeby K, Rathor N, Adrian CL
Consent to participate Informed written consent was obtained from all patients included in the study
Abbreviations and Acronyms CKD = chronic kidney disease GLP-1 = glucagon-like peptide-1 GLP-1 RA = glucagon-like peptide-1 receptor agonist HFpEF = heart failure with preserved ejection fraction MACE = major adverse cardiovascular events NNH = number needed to harm NNT = number needed to treat RCT = randomized controlled trial SAE = serious adverse event Funding Support and Author Disclosures Dr Galli has received consulting fees from Genomadix
The blue, red, cyan, and magenta curves show the time courses of the percent functional hepatocytes if the rescue dose is given at 6, 10, 14, 18 hours respectively
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