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Here we observed an increase of pRb phosphorylation in pancreatic islets treated with exendin-4 and a raise in E2f1 expression in Min6 cells treated with exendin-4, suggesting that -cell proliferation induced by Glp1r agonist could be under the control by the E2F1-pRb pathway

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For adults, the daily dosage typically ranges from 4 to 48 mg, which can be taken as a dose or divided into multiple doses

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Scenarios and data inputs Five scenarios and a further four sensitivity scenarios are presented here (Supplementary Table 1)