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We confirmed both in vitro and in vivo that specific combination of ligands of different transporters, especially alanine and glutathione, is more efficient than single ligands to facilitate the penetration of nanocarrierss across the BBB [24, 32, 33, 42]

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In our cohort, the majority of patients exhibited active IIH, especially in the UCWM group with significantly shorter disease duration, with slightly higher yet not significant change in the pRNFL thickness in this group

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