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Patients initiating tirzepatide should be counseled about the importance of reporting any significant mood changes, cognitive difficulties, or psychological distress

Triple agonists combining GLP 1, GIP and glucagon receptor activity represent another frontier with early data suggesting these may produce even greater weight loss and metabolic improvements

For all experiments, if not otherwise stated, DBA1/J female mice (8 weeks old) were used and purchased from Janvier Labs

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