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While more severe forms are not all that common, some research estimates that MCAS could affect up to 17% of the population on a spectrum from very mild to debilitating symptoms.[ref] Others include very mild symptoms such as allergic rhinitis in the mast cell activation spectrum, which includes up to 30% of the population.[ref]

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Functional alterations in protein kinase C beta II expression in melanoma

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Neoepitopes, tumor-associated antigens, and/or viral oncoproteins are assumed to be the sources of the skin malignancies' antigenicity