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In HG-induced human renal proximal tubule cells (HK-2) and high-fat diet-fed combined streptozotocin (HFD/STZ)-induced diabetic mouse models, ubiquitin-like with PHD and ring finger domains 1 (UHRF1) overexpression through inhibition of thioredoxin-interacting protein (TXNIP) expression promotes PINK1 mediated mitophagy by inhibiting TXNIP expression, thereby inhibiting ferroptosis [117]

the reason for this is still unclear and likely involves complex biological and societal influences

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Secretion of extracellular vesicles from kidney proximal tubules was increased in kidney stones mice and patients To investigate the role of extracellular vesicle (EV) secretion in nephrolithiasis, we examined 3 genes, Rab27a , Rab27b and Smpd3 (Fig

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