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However, UBXD8, a protein in the ER-associated degradation (ERAD) pathway, can bind PNPLA2, preventing the interaction with ABHD5, thereby segregating PNPLA2 to valosin-containing protein (VCP)/p97 segragrase that promotes extraction and subsequent Ub-dependent degradation (132) (Figure 1)
Energies 15 , 7560 (2022)
The benzyl preservative preservative inhibits microbial growth, allowing a single vial to be punctured multiple times over a 28-day window when stored at 28C
If your protocol requires single-use vials or doses administered within 72 hours, sterile water is acceptable
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