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Inclusion criteria were any treatment report of GSH for skin lightening (or hyperpigmentation) and GSH for any randomised control trial (RCT) for the first and second searches, respectively

Ozempic increases hypoglycaemia risk when combined with sulphonylureas (such as gliclazide) or insulin therapy

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This difference was statistically significant

Furthermore, a large proportion of patients refuse, are not satisfied or are not eligible for these strategies, leaving these patients without an efficient therapeutic solution 15

doi: 10.1104/pp.106.089458