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Key perioperative risk domains relevant to TJA and implant-based surgery potentially affected by peptide exposure are summarized in Table 4

Copper-binding tripeptides most notably GHK-Cu (glycyl-L-histidyl-L-lysine complexed with Cu(II)) are the most-cited compounds in cosmetic and wound-research literature, characterised by Pickart and colleagues across fibroblast collagen-synthesis assays, broad gene-expression modulation, and the antioxidant chemistry of the Cu(II) coordination centre

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This could explain why when exogenous l-carnitine was supplied, the already highly up-regulated mitochondrial -oxidation could be effective at reducing the accumulated lipid