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This variant is very rare in gnomADv4.1.0 (0.00003036) and in a TopMED Freeze 10 database (0.000046389)

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It plays an important role in protecting cells against oxidative stress by helping neutralise free radicals generated through normal metabolism and environmental exposures

Deglycyrrhized Licorice Root Extract (DGL) DGL is a form of licorice root that has been specially processed to contain only biologically active flavonoids, without glycyrrhizin

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Oxygen reacts with these amino acids, altering their structure and potentially destroying biological activity