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In the pig LR3 IGF-1 study, plasma endogenous IGF-1 was suppressed during infusion (Tomas et al., 1997), and the guinea pig study showed reduced plasma IGF-I and IGF-II during LR3 administration (Bastian et al., 1995)

Villanueva, J

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found that anti-inflammatory bacterial groups such as Bacteroides and the Clostridium leptum subgroup are reduced in those diagnosed with depression (Mason et al., 2020), suggesting that gut dysbiosis, especially the decrease of these anti-inflammatory regulatory bacteria, plays an important role in the pathophysiology of depression

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