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Glucagon-like peptide-1 (GLP-1) is a part of a family of peptide hormones known as incretins

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Thus, in addition to a potential effect in fostering GLP-1R-stimulated cAMP production, decreased GRK2 levels could reduce incretin-induced GLP-1R phosphorylation and subsequent recruitment of -arrestins, thus leaving more -arrestin 1 available to exert its positive effects on EPAC2