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Creates dose-dependent effects that diverge sharply: sexual function enhancement occurs at 0.51.5mg, while pigmentation changes require sustained doses above 1.5mg daily

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Yu, Y., Cui, Y., Niedernhofer, L

Thats because many patients have rebounded after cessation, Carroll says

5.1.3 Cardiac fibrosis and remodeling Fibrosis, remodeling and hypertrophy are the most crucial pathomechanisms within HF (179), although not completely stopped or even reversed