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In this study we employed structure-based site-directed mutagenesis together with pharmacological assays to compare agonist efficacy across two key signaling pathways, cAMP accumulation and ERK1/2 phosphorylation (pERK1/2)

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doi: 10.1124/mol.109.061366 212 AzarBVaghefiMSMaryamNHelderANedaMNEffatA

Some might even find it lasts up to 8 weeks, but we prefer to err on the side of caution for critical research