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It enhances the activity of CREB, a transcription factor that regulates the expression of genes involved in memory consolidation, and promotes the production of BDNF, or brain-derived neurotrophic factor, a protein that acts as a kind of molecular fertilizer for neurons, supporting their survival, growth, and the formation of new synaptic connections [15]

Phase 3 TRIUMPH-4: 28.7% at 68 weeks

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Further incretin-based drug development For both GIP and GLP-1, positive effects were also observed on cardiovascular complications [23], indicating a therapeutic potential beyond the improvement of diabetes complications

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BMJ 381:e074068