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Nature 289:514516

No secondary indication is required

black pepper (Piper nigrum L.) fruit extract with 95% piperine 2 mg (piperine 1.9 mg)

Colonoscopy is the gold-standard diagnostic and therapeutic procedure for lower GI bleeding, allowing visualization, biopsy, and polyp removal

Never use 12.7 mm (half inch) needles for routine subcutaneous GLP-1 delivery

The authors conclude that individuals starting on tirzepatide can be stratified based on their baseline eye disease status: those with moderate-to-severe non-proliferative retinopathy or maculopathy should have their eye disease closely monitored, whilst those with less severe retinopathy do not require any additional screening