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If left unattended, the deficiency can lead to anemia, as well as nerve and brain damage, which may eventually become irreversible

Meloni et al

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Patients with hyperacute liver failure (defined as development of encephalopathy within 7 days of onset of illness) generally have a good prognosis with medical management, whereas those with subacute liver failure (defined as development of encephalopathy within 5 to 26 weeks of onset of illness) have a poor prognosis without liver transplant

doi: 10.1021/pr100340p 178 TakenoS.SakuradaniE.TomiA.Inohara-OchiaiM.KawashimaH.ShimizuS

(2) CJC-1295 clinical trial data showing GHRH-R-mediated GH/IGF-1 elevation (Teichman et al