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Across the trials, the drugs were linked to reductions in binge eating severity, less disinhibited eating (where people struggle to resist food despite not being physically hungry), and fewer episodes of feeling out of control while eating

These benefits were achieved without serious adverse effects, and GLP-1 RA use was associated with reduced reliance on acetazolamide and avoidance of surgical interventions

J Med Internet Res 22(3):e16791

Reduced abdominal pressure : Visceral fat pushes the diaphragm upward, reducing lung volume and making the airway more collapsible

Therefore, hepatotoxicity induced by APAP is largely necrotic and caspase independent (Jaeschke et al., 2006, 2011)