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This is in agreement with a number of previous studies that showed expression of GPX3 by bronchial epithelial cells and presence in the ELF 36,47

doi: 10.1378/chest.09-0421

Methotrexate and its mechanisms of action

Fadini GP, Frison V, Rigato M, et al

The vascular endothelium modulates muscle perfusion through NOmediated vasodilation, whereas skeletal muscle subsequently secretes myokines such as interleukin-6 (IL-6), irisin, and vascular endothelial growth factor (VEGF), which influence endothelial cell activity, angiogenesis, and vascular remodeling (16, 17)

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