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Interactions between resident immune cells in the CNS and peripheral immune cells through immune molecules render inflammation systemic, ultimately leading to the dysfunction of neuromuscular junctions, damage to motor neuron axons, and motor neuron death [255]

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PMID:11035391 [8] Hruby VJ, Lu D, Sharma SD, Castrucci AL, Kesterson RA, al-Obeidi FA, Hadley ME, Cone RD