Fertil Steril 2015;103:127888, e4
However, a recent study has identified specific genes with their SNP to be the predisposing factor
Metformin Metformin is a biguanide with a complex mechanism of action that produces multiple biologic effects, but the main mechanism of action that has been described is through the adenosine monophosphate-activated protein kinase (AMPK) enzymatic complex
So, the problem doesnt appear to be directly driven by hyperglycemia but possibly by other factors related to oxidative stress and inflammation two major culprits in chronic diseases like diabetes
Focus on Hydration Tirzepatide can affect your thirst signals
Diabetes 52:24612474 Storgaard H, Jensen CB, Vaag AA et al (2003) Insulin secretion after short- and long-term low-grade free fatty acid infusion in men with increased risk of developing type 2 diabetes