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HSP70 and HSP90 in neurodegenerative proteinopathies HSP70 and HSP90 interact with a wide spectrum of disease-associated proteins implicated in NDDs, including amyloid- (A), tau, -synuclein, and TAR DNA-binding protein 43 (TDP-43)

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Additionally, key glycolytic enzymes such as aldolase, triosephosphate isomerase, GAPDH, phosphoglycerate mutase 1, and enolase become functionally impaired due to oxidative stress in AD, reducing glucose metabolism efficiency

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