This phenomenon, often called metabolic adaptation, has been observed in studies on dieting and weight loss
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Healthcare , 9 (4), 402
Replenishing the nutritional status of the host by increasing vital amino acids such as cysteine to enhance GSH levels and selenium to improve selenium deficiency and facilitate selenoprotein (GSH peroxidases, thioredoxin reductases) expression can inhibit oxidative stress, modulating inflammation, suppressing endothelial dysfunction, and protecting vascular cells against apoptosis and calcification (He et al., 2017
It might mean the dose needs increasing, or there are dietary or lifestyle factors interfering with results