The UPR is a signaling pathway activated by ER stress that tries to promote protein refolding or clearance, and if unsuccessful, activates apoptotic pathways [218]
Trotsenburg AS, Van P, Vulsma T, Rutgers SL, Rozenburg-Marres V, Van Baar AL, Ridder JCD, Heymans HSA, Tijssen JGP, De Vijlder JJM (2005) The Effect of Thyroxine Treatment Started in the Neonatal Period on Development and Growth of Two-Year-Old Down Syndrome Children: A Randomized Clinical Trial
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It appears that the most robust predictor for an incident occurrence of DT or seizures is a history of a similar event.3, 10, 24, 25 Clinical findings such as elevated heart rate, systolic blood pressure, and temperature are all easily verifiable in the initial patient assessment, although their predictive value to identify patients with AWS who are more likely to develop DT is not high.3, 10, 26 In a patient with impaired consciousness, laboratory markers represent helpful tools to confirm the suspected clinical diagnosis of an AUD
The push usually lasts between 5 and 15 minutes
