Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial
All migraine characteristics (such as frequency, intensity, duration of attacks and number of medications taken, and migraine disability) were significantly improved in the all groups
Easy measuring: At ~3,333 mcg/mL, 300 mcg 9 units and 500 mcg 15 units on a U-100 insulin syringe
pubmed.ncbi.nlm.nih.gov/22074294 Vasireddi N, et al
Pharmacodynamic Effects and Duration Despite measurable plasma clearance, pharmacodynamic effects extend well beyond plasma half-life[20]: Weight loss effects continue throughout treatment with no plateau observed within 48-week study periods Glycemic improvements persist between weekly doses with stable glucose control Appetite suppression effects remain consistent throughout dosing intervals Tissue receptor occupancy likely exceeds plasma peptide concentrations This disconnect between pharmacokinetics and pharmacodynamics suggests prolonged receptor engagement, tissue depot effects, or persistent downstream signaling cascade activation
Another high-altitude French observatory at Saint-Vran was also capturing the transit of Io's shadow when it picked up the flash