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Numbness and weakness occurring together most often point to a nerve problem either in the peripheral nervous system (such as peripheral neuropathy, a herniated disc, or carpal tunnel syndrome) or the central nervous system (such as stroke, MS, or spinal cord compression)

In addition, one episode of severe hypoglycemia requiring intravenous glucose was reported in a semaglutide-treated patient

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[13] Dosing at night is thought to mimic the natural physiologic rhythm, as endogenous GH release is highest during sleep