Native IGF-1 binds IGFBP-3, the dominant carrier protein in circulation, with a dissociation constant in the low nanomolar range (Kd approximately 0.1 to 1 nM in most published binding assays)
A study published in the Journal of Clinical Endocrinology found that patients with autoimmune thyroiditis had significantly higher HOMA-IR scores (a measure of insulin resistance) than matched controls, regardless of TSH levels
The trial enrolled 120 adult participants with obesity or overweight (BMI 2738 kg/m) but without diabetes or significant comorbidities
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Peer review Peer review information Nature Metabolism thanks Darleen Sandoval and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
The SELECT clinical trial results found a statistically significant drop, among trial subjects taking a GLP-1, in hospitalizations and surgeries considered serious adverse events