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Effectiveness depends on the research goal

(61), E2 treatment was observed to increase the activity of antioxidant enzymes in the tissues of OVX rats while concurrently exacerbating oxidative stress levels

Well-designed randomized clinical studies are needed to systematically evaluate the evidence for the use of these hepatoprotective agents as treatment options for APAP-induced liver injury, to determine the timing of initiation of the therapy, and to further define the optimal treatment regimen

Short-term soy isoflavone intervention in patients with localized prostate cancer: a randomized, double-blind, placebo-controlled trial