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In this setting, CYB5R3 functions not only as a preserver of hemoglobin activity but also as a responsive regulatory valve controlling NO signaling within RBCs
All in vivo experiments were carried out in accordance with regulations regarding the care and use of experimental animals, and the Danish Animal Experimentation Inspectorate approved the experimental procedures (2018-15-0201-01457)
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In our study data, we found no Qualifying variants in CNR1
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Thus, the assay using cumene hydroperoxide or tert-butyl hydroperoxide measures selenium-dependent GPx and activity from glutathione S-transferases (selenium-independent GPx) 7 , 15
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