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In some embodiments, the osmolarity at a target site of action (e.g., the perilymph) is about the same as the delivered osmolarity (i.e., osmolarity of materials that cross or penetrate the round window membrane) of any formulation described herein

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The CoQ provides antioxidant protection to cell membranes and plasma lipoproteins

Evidence for oxidation at C-3 of the flavonoid C-ring during anthocyanin biosynthesis