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Unlike some peptides where more is simply better, IGF-1 LR3 has a relatively narrow therapeutic window

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It provides the bioavailability needed for these effects

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However, as a precaution, tirzepatide is contraindicated in individuals with a personal or family history of MTC or multiple endocrine neoplasia syndrome type 2 (MEN 2)

The article discusses the pharmacokinetic challenges peptides face, such as low oral bioavailability due to poor membrane permeability and enzymatic degradation in the gastrointestinal tract