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The lack of PD symptoms in older patients with DLB is consistent with the notion that dopaminergic neuronal cell death due to neuroinflammation at the substantia nigra is not critical in DLB

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However, the pharmacokinetics of cagrilintide are dose-proportional and linear, with exposure determined primarily by apparent clearance (CL/F) at any administered dose, and AUC defined as dose/(CL/F), thus allowing direct comparison across different dosing regimens

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