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They are neuroimmune sentinels capable of detecting danger signals, orchestrating inflammation, and influencing the trajectory of autoimmune disease

M.et al (2012)

Oxidative stress: a unique vulnerability points of beta cells Oxidative stress represents a critical and destructive biochemical process that underlies the metabolic abnormalities in type 1 diabetes (T1D) [81]

Since insulin therapy often indicates more advanced disease progression, greater severity, or additional comorbidities, which may lead to a higher risk of intestinal obstruction, and there was no statistically significant difference in intestinal obstruction risk between GLP-1RAs and other anti-diabetic medications (e.g., SGLT2 inhibitors, metformin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors), the observed reduction relative to insulin does not necessarily suggest a protective effect of GLP-1RAs against intestinal obstruction

These cardiovascular benefits are particularly important because obesity is a major risk factor for heart disease, stroke, and related conditions

Huang S, Czech MP