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Contraindications: - Personal or family history of medullary thyroid carcinoma (MTC) - Multiple Endocrine Neoplasia syndrome type 2 (MEN2) - Serious hypersensitivity to orforglipron Safety profile: Common adverse effects include nausea, diarrhea, constipation, vomiting, abdominal pain, and fatigue

40% want to make taking the drug easier

GLP-1 (glucagon-like peptide 1) receptor Promotes satiety signaling, slows gastric emptying, and stimulates glucose-dependent insulin secretion

Junnila RK, List EO, Berryman DE, Murrey JW, Kopchick JJ

Many patients see early appetite changes within 12 weeks, with steady loss as dosing progresses

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