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doi: 10.1016/S2468-1253(20)30217-X 2

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Impaired homocysteine metabolism-mediated moderate hyperhomocysteinemia (caused by folate deficiency, vitamin B 6 deficiency, or by methionine excess) might thus have primarily pro-oxidant effects resulting from an altered extra- and intracellular redox potential that can affect essential vascular functions

The search strategy utilized combinations of the following Medical Subject Headings (MeSH) and text words: (gut microbiota OR gastrointestinal microbiome OR dysbiosis) AND (osteoporosis OR bone metabolism OR bone mineral density OR osteoclast OR osteoblast) AND (short-chain fatty acids OR immune regulation OR gut-bone axis OR mechanostat)

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Nature 561 , 137140 (2018)