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Research on semaglutide and liraglutide, including the STEP clinical trial programme, demonstrates that while these medications produce substantial weight loss (typically 10-15% of body weight in clinical trials), the expected metabolic adaptation still occurs

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Although fenfluramine and dexfenfluramine were withdrawn due to safety concerns, phentermine as monotherapy was considered safe and was not withdrawn from the market

84 In the same study, the concept was proven in cancer cell lines by reverting lipid oxidation through the addition of homocysteine

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