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It has been observed to regulate approximately 4,000 human genes, essentially shifting the gene expression of aged cells to resemble that of younger, healthier cells

Stefan is the founder of NGD Care, NGD Care Academy and Integrative Veterinary Center Natural Healthy Animals

Mathematical Framework for Human Equivalent Dose The human equivalent dose (HED) formula is: HED (mg/kg) = Animal dose (mg/kg) (Animal Km / Human Km) Standard Km constants used in pharmacological scaling are: Rat Km = 6 Human Km = 37 To illustrate: If a rat study administers 10 mcg/kg, convert micrograms to milligrams: 10 mcg = 0.01 mg HED = 0.01 (6 / 37) HED 0.00162 mg/kg HED 1.62 mcg/kg For a 70 kg individual: 70 1.62 mcg 113 mcg This represents a mathematically scaled equivalent exposurenot a prescription

This may be particularly important, eg, in the administration of antiarrhythmic drugs such as lidocaine, where an almost immediate toxic response may occur

Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease