(Cochrane Pregnancy and Childbirth Group) (January 2024)
The exact dosage is dependent on medical condition, response to the treatment, age, and weight
It supplies the mechanistic and directional rationale for the whole compound class, but it is not a human trial and does not establish a human dose
This increase in cAMP may activate protein kinase A (PKA), which then appears to phosphorylate hormone-sensitive lipase (HSL) on specific serine sites
For these reasons, supplemental vitamin B12 is proposed for treating neuropathy , as it may alleviate pain by increasing nerve regeneration and decreasing ectopic nerve firing (which causes neuropathic pain), as seen in a systematic review of 24 studies
The compound could theoretically interact with medications affecting NAD+ metabolism, energy pathways, or the enzymes responsible for its clearance from the body