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Peroxisome proliferator-activated receptor alpha (PPAR), a key nuclear transcription factor that regulates keratinocyte differentiation and epidermal lipid metabolism, is markedly downregulated in AD (Kuai et al., 2024), leading to impaired barrier integrity and defective lipid synthesis, which further supported by PPAR agonist-induced barrier restoration in ex vivo skin model (Majewski et al., 2021)

In Figure 4D , the HbA1c data indicate that both PNP hydrogel formulations of TZP (4.5 mg/mL) and Sema (1.8 mg/mL) effectively maintained or modestly reduced glycemic levels over 6 weeks following a single injection, demonstrating sustained therapeutic activity

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Candida albicans and cancer: can this yeast induce cancer development or progression