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Rezafungin (Rezzayo) is a kind of white spines, inhibits1, 3--D-glucan synthase

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doi:10.1007/s00394-019-01998-3 Shea MK, Barger K, Booth SL, et al

The regulation of the VHLHIF pathway is also related to iron metabolism and ferroptosis in ccRCC, as iron levels are significantly higher in RCC cells and the tumor microenvironment than in normal renal tissue (77), and as HIF-1 mediates the cellular upregulation of TfRC and heme oxygenase (HO) expression, promoting cellular iron accumulation (78, 79)

A heatmap of associated CpG sites using beta values revealed distinct methylation patterns compared to controls (Figure 3B)