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Most patients report a mild cooling sensation as the fluid infuses, and many use the time to rest or to sit with numbing cream if a treatment appointment follows the IV

This is called dehydration

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Interestingly, p38 exhibits context-dependent effects: under physiological conditions (e.g., exercise), p38 promotes mitochondrial biogenesis and fiber-type remodeling (Vainshtein and Sandri, 2020)

Nausea typically diminishes, though appetite suppression remains strong

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